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Supplementary tables S4-S7 report the distribution of case and controls based on the deemed covariates, usage of personal NSAIDs, and dose types of recent NSAIDs use (in DDD equivalents and corresponding everyday degree of Lively principle in mg), in addition to the results of individual NSAIDs on the heart failure possibility.

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Relative risk estimates for individual NSAIDs amid clients with prior outpatient or secondary clinic diagnoses of coronary heart failure (that is, Those people which has a contraindication for NSAID use who also need to be a lot more inclined for acute scientific manifestations of heart failure) did not manage to differ substantially from Individuals obtained in the overall analysis. Taken alongside one another, these outcomes deliver some safety to our results. Nevertheless, we cannot exclude that residual dissimilarities in patient's baseline features could account for many of the observed versions in relative threat estimates connected to distinctive particular person NSAIDs.

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Every single cohort member accumulated particular person several years of abide by-up, within the day of cohort entry for the earliest day of outcome onset (day of very first healthcare facility admission by using a Main diagnosis of heart failure), censoring (conclude of registration within the database because of death or emigration), diagnosis of malignancy (excluding non-melanoma pores and skin cancers), or end of database distinct details availability.

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